3 edition of Na+/H+ exchanger found in the catalog.
Includes bibliographical references and index.
|Series||Molecular biology intelligence unit|
|LC Classifications||QP535.N2 F57 1996, QP535.N2 F57 1996|
|The Physical Object|
|Pagination||317 p. :|
|Number of Pages||317|
|LC Control Number||96000195|
The pH milieu of the central and peripheral nervous systems is an important determinant of neuronal excitability, function, and survival. In mammals, neural acid–base homeostasis is coordinately regulated by ion transporters belonging to the Na + /H + exchanger (NHE) and bicarbonate transporter gene families. However, the relative Cited by: 5. Title: The Na+/H+ exchanger present in trout erythrocyte membranes is not responsible for the amiloride-insensitive Na+/Li+ exchange activityCited by: 2.
The control by Na+/H+ antiporters of sodium/proton concentration and cell volume is crucial for the viability of all cells. Adaptation to high salinity and/or extreme pH in plants and bacteria or. Sodium/hydrogen transporters are ubiquitous transmembrane (TM) 3 proteins that transport Na + and H + ions across the membrane, and are therefore imperative for vital cellular processes such as regulation of cellular pH, cell volume, and ion composition ().The mammalian Na + /H + exchanger (NHE) family of transporters includes nine isoforms (NHE1 through NHE9), of which .
On the basis of intracellular acidifications in the presence of 30 μM cariporide, we selected a fibroblast cell line termed CR5, expressing a mutated Na + /H + exchanger NHE-1 with a low affinity for cariporide (87 ± μM) and extracellular sodium ( ± mM). This mutated exchanger displays a PheSer substitution in its fourth transmembrane segment. Loss-of-function mutations in human endosomal Na + (K +)/H + exchangers (NHEs) NHE6 and NHE9 are implicated in neurological disorders including Christianson syndrome, autism, and attention deficit and hyperactivity disorder. These mutations disrupt retention of surface receptors within neurons and glial cells by affecting their delivery to lysosomes for degradation.
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The Na+/H+ Exchanger (Molecular Biology Intelligence Unit): Medicine & Health Science Books @ Buy Na+/H+ Exchanger Books online at best prices in India by Larry Fliegel from Buy Na+/H+ Exchanger online of India’s Largest Online Book Store, Only Genuine Products. Lowest price and Replacement Guarantee.
Cash On Delivery Available. In this context, one of the primary and best studied regulators of both pHi and pHe in tumors is the Na+/H+ exchanger isoform 1 (NHE1). The NHE1 is an integral membrane transport protein involved in regulating pH and in tumor cells is a major contributor to the production and maintenance of their reversed proton gradient.
Focusing on the NA+/H+ Exchanger, this text discusses the protein and its recently-characterized isoforms. The work compares these isoforms with other NA+/H+ Exchanger isoforms of non-mammalian species, and shows the role of the protein in the contractile failure associated with ischaemia.
Sodium/hydrogen exchanger 6 is an integral membrane protein that in humans is encoded by the SLC9A6 was originally thought to be a mitochondrial-targeted protein, but subsequent studies have localized it to the plasma membrane and recycling endosomes. Loss of function causes Christianson syndrome.
See also. SLC9A6+protein,+human at the US National Library of Medicine Aliases: SLC9A6, MRSA, NHE6, solute carrier family 9. Rice (Oryza sativa) stands among the world's most important crop species. Rice is salt sensitive, and the undue accumulation of sodium ions (Na+) in shoots has the strongest negative correlation with rice productivity under long-term salinity.
The plasma membrane Na+/H+ exchanger protein Salt Overly Sensitive 1 (SOS1) Na+/H+ exchanger book the sole Na+ efflux transporter that has been genetically Cited by: 9. Sodium-hydrogen exchangers (Na + /H + exchangers, NHE) are ATP-independent membrane glycoprotein transporters that are involved in the regulation of intracellular pH, cell volume and the cellular response to hormones and mitogens.
The transporters mediate the simultaneous efflux of a hydrogen ion and the influx of a sodium ion across the Na+/H+ exchanger book membrane, the driving force being the inwardly.
Structure and function of the human Na+/H+ exchanger isoform 1. Kemp G(1), Young H, Fliegel L. Author information: (1)Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada. Sodium proton exchangers (NHEs) constitute a large family of polytopic membrane protein transporters found in organisms across all domains of by: INTRODUCTION.
The mammalian NHE (Na + /H + exchanger) is an integral membrane protein that functions to exchange one intracellular proton for one extracellular sodium ion.
By its involvement in ion fluxes, the NHE serves to regulate pH i (intracellular pH) and cell volume, and to initiate changes in the growth or functional state of cells .Aside from its physiological role, the NHE Cited by: Isoform one of the mammalian Na+/H+ exchanger is a plasma membrane protein that is ubiquitously present in humans.
It regulates intracellular pH through the removal of one intracellular proton in exchange for a single extracellular sodium. It consists of a amino acid membrane domain plus a amino acid, C-terminal tail.
We examined amino acids of the C-terminal tail that are important in Author: Xiuju Li, Debajyoti Dutta, Debajyoti Dutta, Martin Jung, Richard Zimmermann, Larry Fliegel.
Na+/H+ exchange was first described by Murer et al. () in a study of intestinal and renal brush-border vesicles. The plasma membrane Na/H exchanger is an ubiquitous pH-regulating cellular ion. Glc regulates many vital processes, including plant growth, development, metabolism, and responses to biotic and abiotic stress.
However, the molecular mechanism by which Glc acts as a signal to regulate salinity tolerance remains unclear. In this study, we found that the apple (Malus domestica Borkh.) Glc sensor hexokinase1 (MdHXK1) contributes to Glc-mediated salinity by: Na+-H+ Exchanger, pH Regulation and Cancer.
In this context, one of the primary and best studied regulators of both pHi and pHe in tumors is the Na+/H+ exchanger isoform 1 (NHE1). The NHE1 is. The human Na+/H+ exchanger isoform 1 (NHE1) is a plasma membrane transport protein that plays an important role in pH regulation in mammalian cells.
Because of the generation of protons by intermediary metabolism as well as the negative membrane potential, protons accumulate within the cytosol. Extracellular signal-regulated kinase (ERK)-mediated regulation of NHE1 is important in several Cited by: 3. I am extremely honored and pleased to have the opportunity to write a few introductory words for this timely volume on Na + /It exchange.
This is a field of investigation that I entered into by challenge and necessity, embraced with passion and fmally left in my quest for new discoveries in growth.
Sodium-Hydrogen-Exchanger Regulator FactorNull Mice. Sodium-hydrogen-exchanger regulator factor-1 (NHERF-1)-null mice, at 12 weeks old, have normal urinary volume and experience hypercalciuria, hyperphosphaturia, hypermagnesuria, and uric aciduria. At 6 months of age, there is a correction in the urinary phosphate/creatinine ratio.
By 1. Robert W. Putnam, in Cell Physiology Source Book (Fourth Edition), Intracellular pH is an important aspect of the intracellular environment. Changes in intracellular pH can potentially affect virtually all cellular processes, including metabolism, membrane potential, cell growth, movement of substances across the surface membrane, state of polymerization of the cytoskeleton and ability.
title = "Na+/H+-exchanger 3 activity and its gene in the spontaneously hypertensive rat kidney", abstract = "Objective. To examine the mechanisms affecting proximal tubule sodium reabsorption, we studied the gene expression and functional changes of the Na+/H+-exchanger 3 (NHE3) and its gene expression in spontaneously hypertensive rats (SHR).Cited by: Regulation of Na+/H+ Exchanger Isoform 3 by Protein Kinase A in the Renal Proximal Tubule.
By Adriana Castello Costa Girardi and Luciene Regina Carraro-Lacroix. Submitted: May 25th Reviewed: February 2nd Published: June 5th DOI: /Author: Adriana Castello Costa Girardi, Luciene Regina Carraro-Lacroix. The Na+/H+ exchanger isoform 1 (NHE1) is a ubiquitously expressed transporter fulfilling a variety of cell physiological tasks.
By importing Na+ and exporting H+, NHE1 contributes to regulatory volume increase and cytoplasmic pH homeostasis. In addition it anchors the cytoskeleton in the plasma by:. Prepared by leading scientists in the field, these volumes compile for the first time, concise, up-to-date reviews of several aspects of the basic properties, distribution, function and regulation of the Na+/H+ antiport.
In addition, current methods and the use of inhibitors and ligands for .Na+/H+ exchanger isoform 1 (NHE1) is found in virtually all tissues and cells in mammals and is involved in numerous physiological processes, including regulation of intracellular pH, cellular volume, cytoskeletal organisation, heart disease and cancer [11, 12, 13].
In epithelial cells, NHE1 is largely restricted to the basolateral membrane.Xiang et al. () found that heterologous expression of human NHA2 in yeast lacking endogenous cation/proton antiporters and pumps conferred tolerance to Li+ and Na+ ions, but not K+ ions. Salt tolerance appeared to be achieved by cation extrusion.
Complementation for both LiCl and NaCl sensitivity was optimal between pH and and required the conserved aspartic acids at positions .